Meningococcal
Conjugate Vaccine
Meningococcal (Groups A, C, Y and W-135) Conjugate Vaccine (MCV-4)
ACIP Recommends Meningococcal Vaccine for Adolescents and
College Freshmen
The
Advisory Committee on Immunization Practices (ACIP) to the Centers
for Disease Control and Prevention (CDC) recommends routine
vaccination of young adolescents with MCV4 at the pre-adolescent
visit (11-12 year old). Introducing a recommendation for MCV4
vaccination in young adolescents (11-12 years old) may strengthen
the role of the pre-adolescent visit and have a positive effect on
vaccine coverage in adolescence. ACIP recommends that young
adolescents see a healthcare provider at age 11-12 for a routine
preventive visit, at which time appropriate immunizations and other
preventive services should be provided. For those who have not
previously received MCV4, we recommend vaccination before high
school entry (~15 years old) as the most effective strategy towards
reducing meningococcal disease incidence in adolescence and young
adulthood. Within 3 years, the goal is routine vaccination with MCV4
of all adolescents beginning at 11 years of age. ACIP recognizes
that vaccine supply may be an issue in the first few years after
licensure of MCV4. Other adolescents who wish to decrease their risk
of meningococcal disease may elect to receive vaccine.
College freshman who live in dormitories are at higher risk for
meningococcal disease compared to other people of the same age.
Because of the feasibility constraints in targeting freshmen in
dormitories, colleges may elect to target their vaccination
campaigns to all matriculating freshmen. The risk for meningococcal
disease among non-freshmen college students is similar to that for
the general population of similar age (18-24 years). However, the
vaccines are safe and immunogenic and therefore can be provided to
non-freshmen college students who want to reduce their risk for
meningococcal disease.
Meningococcal disease is caused by bacteria that infect the
bloodstream and the linings of the brain and spinal cord, causing
serious illness. Every year in the United States, 1,400 to 2,800
people get meningococcal disease. Ten to 14 percent of people with
meningococcal disease die, and 11-19 percent of survivors have
permanent disabilities (such as mental retardation, hearing loss,
and loss of limbs). The disease often begins with symptoms that can
be mistaken for common illnesses, such as the flu. Meningococcal
disease is particularly dangerous because it progresses rapidly and
can kill within hours.
�Disease caused by meningococcal bacteria kills about 300 people
each year in the United States. We are encouraged that today�s ACIP
recommendation will help to prevent this potentially deadly disease
among adolescents� said Dr. Stephen Cochi, Acting Director of the
National Immunization Program at CDC.
The
vaccine is highly effective. However, it does not protect people
against meningococcal disease caused by �type B� bacteria. This type
of bacteria causes one-third of meningococcal cases. More than half
of the cases among infants aged <1 year are caused by �type B,� for
which no vaccine is available in the United States. The new
meningococcal vaccine was licensed by the U.S. Food and Drug
Administration (FDA) on January 14, 2005 for use in people 11-55
years of age. It is manufactured by Sanofi Pasteur and is marketed
as Menactra�.